Endoscopy
Impact of Margin Thermal Ablation on Long-Term Recurrence Following Endoscopic Mucosal Resection of Large Non-Pedunculated Colonic Polyps
O’Sullivan T, Mandarino F, Gauci J, et al. Impact of margin thermal ablation after endoscopic mucosal resection of large (≥20 mm) non-pedunculated colonic polyps on long-term recurrence. Gut 2025; 74: 67-74. doi: 10.1136/gutjnl-2024-332907
Hepatology
Faecal proteomics links neutrophil degranulation with mortality in patients with alcohol-associated hepatitis
Kreimeyer H, Gonzalez C, Fondevila M, et al. Faecal proteomics links neutrophil degranulation with mortality in patients with alcohol-associated hepatitis. Gut 2025; 74: 103-115. doi: 10.1136/gutjnl-2024-332730
Helicobacter pylori
Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-EuReg)
Olmedo L, Calvet X, Gené E, et al. Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-EuReg). Gut 2025; 74: 15-25. doi: 10.1136/gutjnl-2024-332804.
GI Cancer
Epidemiology of gastrointestinal cancers: a systematic analysis
Danpanichkul P, Suparan K, Tothanarungroj P, et al. Epidemiology of gastrointestinal cancers: a systematic analysis from the Global Burden of Disease Study 2021. Gut 2025; 74: 26-34. doi: 10.1136/gutjnl-2024-333227
Neurogastroenterology
Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation
Wilkinson-Smith V, Scott M, Menys A et al. Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study. Gut 2025; 74: 35-44. doi: 10.1136/gutjnl-2024-332755
Gut Microbiota
Association of breast milk-derived arachidonic acid- induced infant gut dysbiosis with the onset of atopic dermatitis
Jiang S, Cai M, Li D, et al. Association of breast milk-derived arachidonic acid-induced infant gut dysbiosis with the onset of atopic dermatitis. Gut 2025; 74: 45-57. doi: 10.1136/gutjnl-2024-332407
Reviewers
Dr Gaurav Nigam, NIHR Clinical Research Fellow, University of Oxford and Oxford University Hospitals, Oxford, UK
Dr Brian Ho, Honorary Clinical Research Fellow and Gastroenterology Registrar, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK
Dr Anahita Sharma, Gastroenterology Registrar, Department of Gastroenterology, Arrowe Park Hospital, Wirral, UK
Dr Nurulamin Noor, Clinical Lecturer in Gastroenterology, University of Cambridge and Cambridge University Hospitals, Cambridge, UK
Dr Keith Pohl, JAG Fellow and Gastroenterology Registrar, Torbay and South Devon NHS Foundation Trust, Torquay, UK
Dr Akudo Nwaogu, Gastroenterology Registrar, Department of Gastroenterology, Kingston Foundation Hospital Trust, London, UK
BSG GUT Highlights is edited by Dr Philip J Smith, Honorary Consultant Luminal Gastroenterologist, Royal Liverpool Hospital, Liverpool University Hospitals NHS Foundation Trust, Mount Vernon, Liverpool, UK. Dr Smith is the Digital and Education Editor of GUT, Editor in chief of Frontline Gastroenterology and Associate Editor of BMJ Open Gastroenterology.
Funding
The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests:
None declared.
Provenance and peer review:
Not commissioned; internally peer reviewed.