Coeliac Disease
Persistent villous atrophy predicts development of complications and mortality in adult patients with coeliac disease - Schiepatti A, Maimaris S, Raju S et al.
Schiepatti A, Maimaris S, Raju S et al. Persistent villous atrophy predicts development of complications and mortality in adult patients with coeliac disease: a multicentre longitudinal cohort study and development of a score to identify high-risk patients. Gut 2023; 72(11): 2095-2102. doi: 10.1136/gutjnl-2023-329751.
Colon
Revealing and harnessing CD39 for the treatment of colorectal cancer and liver metastases by engineered T-cells - Potenza A, Balestrieri C, Spiga M, et al.
Potenza A, Balestrieri C, Spiga M, et al. Revealing and harnessing CD39 for the treatment of colorectal cancer and liver metastases by engineered T-cells. Gut 2023; 72: 1887-1903. doi: 10.1136/gutjnl-2022-328042
Endoscopy
Treatment of adenoma recurrence after endoscopic mucosal resection - Tate D, Desomer L, Argenziano M, et al.
Tate D, Desomer L, Argenziano M, et al. Treatment of adenoma recurrence after endoscopic mucosal resection. Gut 2023; 72: 1875-1886. doi: 10.1136/gutjnl-2023-330300
Technical performance and diagnostic yield of motorised spiral enteroscopy compared with single-balloon enteroscopy in suspected Crohn’s disease - Pal P, Ramchandani M, Banerjee R, et al.
Pal P, Ramchandani M, Banerjee R, et al. Technical performance and diagnostic yield of motorised spiral enteroscopy compared with single-balloon enteroscopy in suspected Crohn’s disease: a randomised controlled, open-label study (the MOTOR-CD trial) Gut 2023; 72: 1866-1874. doi: 10.1136/gutjnl-2023-329885.
Gut Brain Axis
Gastrointestinal syndromes preceding a diagnosis of Parkinson’s disease: testing Braak’s hypothesis using a nationwide database for comparison with Alzheimer’s disease and cerebrovascular diseases. - Konings B, Villatoro L, Van den Eynde J, et al.
Konings B, Villatoro L, Van den Eynde J, et al. Gastrointestinal syndromes preceding a diagnosis of Parkinson’s disease: testing Braak’s hypothesis using a nationwide database for comparison with Alzheimer’s disease and cerebrovascular diseases. Gut 2023; 72: 2103-2111. doi: 10.1136/gutjnl-2023-329685.
Helicobacter Pylori
Three-in-one single capsule bismuth quadruple therapy is more effective at three than four times daily dosing. - Pérez-Aisa A, Nyssen O, Keco-Huerga A et al.
Pérez-Aisa A, Nyssen O, Keco-Huerga A et al. Bismuth quadruple three-in-one single capsule three times a day increases effectiveness compared with the usual four times a day schedule: results from the European Registry on Helicobacter pylori Management (Hp-EuReg). Gut 2023; 72(11): 2031-2037. doi: 10.1136/gutjnl-2022-329259
Hepatology
A multiomics margin morphology classification system for hepatocellular carcinoma - Fan Z, Jin M, Zhang L, et al.
Fan Z, Jin M, Zhang L, et al. From clinical variables to multiomics analysis: a margin morphology-based gross classification system for hepatocellular carcinoma stratification. Gut 2023; 72(11): 2149-63. doi: 10.1136/gutjnl-2023-330461
Liver
Global prevalence of non-alcoholic fatty liver disease in type 2 diabetes mellitus: an updated systematic review and meta-analysis - Cho E, Ang C, Quek J, et al.
Cho E, Ang C, Quek J, et al. Global prevalence of non-alcoholic fatty liver disease in type 2 diabetes mellitus: an updated systematic review and meta-analysis. Gut 2023; 72: 2138-2148. doi: 10.1136/gutjnl-2023-330110.
Microbiota
A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut - Mishra S, Wang B, Jain S, et al.
Mishra S, Wang B, Jain S, et al. A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut. Gut 2023; 72: 1848-1865. doi: 10.1136/gutjnl-2022-327365.
Roseburia intestinalis: a new venue in immunotherapy landscape for colorectal cancer - Kang X, Liu C, Ding Y, et al.
Kang X, Liu C, Ding Y, et al. Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells. Gut 2023; 72: 2112-2122. doi: 10.1136/gutjnl-2023-330291
Oesophagus
Mepolizumab for treatment of adolescents and adults with eosinophilic oesophagitis - Dellon E, Peterson K, Mitlyng B, et al.
Dellon E, Peterson K, Mitlyng B, et al. Mepolizumab for treatment of adolescents and adults with eosinophilic oesophagitis: a multicentre, randomised, double-blind, placebo-controlled clinical trial Gut 2023; 72: 1828-1837. doi: 10.1136/gutjnl-2023-330337
Comparison of drugs for active eosinophilic oesophagitis: systematic review and network meta-analysis - Visaggi P, Barberio B, Del Corso G, et al.
Visaggi P, Barberio B, Del Corso G, et al. Comparison of drugs for active eosinophilic oesophagitis: systematic review and network meta-analysis. Gut 2023; 72: 2019-2030. doi: 10.1136/gutjnl-2023-329873.
Reviewers
- Dr Gaurav Nigam, NIHR Clinical Research Fellow, University of Oxford and Oxford University Hospitals, Oxford, UK
- Dr Keith Pohl, South West Endoscopy Training Academy Leadership Fellow and Gastroenterology Registrar, Torbay and South Devon NHS Foundation Trust, Torquay, UK
- Dr Nurulamin Noor, Clinical Lecturer in Gastroenterology, University of Cambridge and Cambridge University Hospitals, Cambridge, UK
- Dr Anahita Sharma, Gastroenterology Registrar, Department of Gastroenterology, East Lancashire NHS Hospitals Foundation Trust, Burnley, UK
- Dr Akudo Nwaogu, Gastroenterology Registrar, Department of Gastroenterology, King’s College Hospital NHS Trust, London, UK
- Dr Brian Ho, Honorary Clinical Research Fellow and Gastroenterology Registrar, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK
- Dr Benjamin Norton, Doctoral Research Student, Cleveland Clinic London (CCL) and University College London (UCL), London, UK
- Dr Ahmed El-Sayed, Gastroenterology Registrar, Hillingdon Hospital, Hillingdon, London, UK
- Dr Benjamin Zare, St Mark’s National Bowel Hospital & Academic Institute, London, UK
- Dr Puneet Chhabra, Consultant Gastroenterology, Calderdale and Huddersfield NHS Trust, Huddersfield, UK
- Dr Mie Thu Ko, NIHR Academic Clinical Fellow, University of East Anglia and Norfolk and Norwich University Hospital, Norwich, UK
- Dr Mohsen Subhani, Nottingham University Hospitals NHS Trust, Nottingham, UK
BSG Gut Highlights is edited by Dr Philip J Smith, Honorary Consultant Luminal Gastroenterologist, Royal Liverpool Hospital, Liverpool University Hospitals NHS Foundation Trust, Mount Vernon, Liverpool, UK. Dr Smith is the Digital and Education Editor of Gut, Deputy Editor of Frontline Gastroenterology and Associate Editor of BMJ Open Gastroenterology.
Funding
The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests
None declared.
Provenance and peer review
Not commissioned; internally peer reviewed.