Endoscopy
Sphincterotomy for biliary sphincter of Oddi disorder and idiopathic acute recurrent pancreatitis: the RESPOnD longitudinal cohort
Coté G, Elmunzer B, Nitchie H, et al. Sphincterotomy for biliary sphincter of Oddi disorder and idiopathic acute recurrent pancreatitis: the RESPOnD longitudinal cohort. Gut 2025; 74: 58-66. doi: 10.1136/gutjnl-2024-332686
Impact of margin thermal ablation after endoscopic mucosal resection of large (≥20 mm) non-pedunculated colonic polyps on long-term recurrence
O’Sullivan T, Mandarino F, Gauci J, et al. Impact of margin thermal ablation after endoscopic mucosal resection of large (≥20 mm) non-pedunculated colonic polyps on long-term recurrence. Gut 2025; 74:67-74. doi:10.1136/gutjnl-2024-332907
Hepatology
Faecal proteomics Neutrophil Degranulation and mortality in Alcoholic Hepatitis
Kreimeyer H, Gonzalez C, Fondevila M, et al. Faecal proteomics links neutrophil degranulation with mortality in patients with alcohol-associated hepatitis. Gut 2025; 74: 103-115. doi: 10.1136/gutjnl-2024-332730.
Neurogastroenterology
Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study
Wilkinson-Smith V, Scott M, Menys A, et al. Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study. Gut 2025; 74: 35-44. doi: 10.1136/gutjnl-2024-332755.
GI Cancer
Epidemiology of gastrointestinal cancers: a systematic analysis from the Global Burden of Disease Study 2021
Danpanichkul P, Suparan K, Tothanarungroj P, et al. Epidemiology of gastrointestinal cancers: a systematic analysis from the Global Burden of Disease Study 2021. Gut 2025; 74: 26-34. doi: 10.1136/gutjnl-2024-333227.
Helicobacter pylori
Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-EuReg)
Olmedo L, Calvet X, Gené E, et al. Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-EuReg). Gut 2025; 74: 15-25. doi: 10.1136/gutjnl-2024-332804.
Reviewers
Dr Benjamin Norton, Doctoral Research Student, Cleveland Clinic London (CCL) and University College London (UCL), London, UK
Dr Mohsen Subhani, Nottingham University Hospitals NHS Trust, Nottingham, UK
Dr Mie Thu Ko, NIHR ST4 Academic Clinical Fellow, University of East Anglia and Norfolk and Norwich University Hospital, Norwich, UK
Dr Benjamin Zare, St Mark’s National Bowel Hospital & Academic Institute, London, UK
Dr Ahmed El-Sayed, Clinical Research Fellow, UCL, London, UK
Dr Puneet Chhabra, Staff Specialist Gastroenterologist, Royal Hobart Hospital, Hobart, Tasmania, Australia
BSG GUT Highlights is edited by Dr Philip J Smith, Honorary Consultant Luminal Gastroenterologist, Royal Liverpool Hospital, Liverpool University Hospitals NHS Foundation Trust, Mount Vernon, Liverpool, UK. Dr Smith is the Digital and Education Editor of GUT, Editor in chief of Frontline Gastroenterology and Associate Editor of BMJ Open Gastroenterology.
Funding
The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests: None declared.
Provenance and peer review: Not commissioned; internally peer reviewed.